one pot synthesis of polyhydroquinolines catalyzed by sulfonic acid functionalized sba-15 as a new nanoporous acid catalyst under solvent free conditions

sulfonic acid functionalized sba-15 (sba-pr-so3h) as a new nanoporous acid catalyst was used in the one-pot synthesis of polyhydroquinolines derivatives via the hantzsch four component condensation reaction of aldehydes, b-ketoesters, dimedone and ammonium acetate under solvent free conditions with short reaction time in excellent yields. sba-pr-so3h was proved to be an efficient heterogeneous nanoporous solid acid catalyst (pore size 6 nm), which could be easily handled and removed from the reaction mixture by simple filtration, and also recovered and reused without loss of reactivity.